Pyrimethamine, a medicine used to prevent malaria; Warfarin, a medicine used to prevent blood clots; Methotrexate, a medicine used to treat arthritis and some types of cancer; Phenytoin, a medicine used to control epilepsy (fits or seizures); Digoxin, a medicine used to treat heart failure or to control a fast irregular heartbeat; Procainamide, a medicine used to correct an irregular heartbeat or to slow an overactive heart; Zidovudine, zalcitabine or lamivudine; medicines used for certain viral infections; Dapsone, a medicine used for leprosy or dermatitis herpetiformis; Cyclosporin, a medicine used to help prevent organ transplant rejection or to treat certain problems with the immune system; Diuretics, also known as fluid or water tablets; ACE inhibitors, medicines used to treat high blood pressure and some heart conditions. Alprim is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. These thermometers provide the most accurate measurement of core body temperature. Do not take Alprim after the expiry date (EXP) printed on the pack. Do not take ALPRIM if you are allergic to any other medicines containing trimethoprim or any of the ingredients listed at the end of this leaflet. Talk to your doctor about the need for additional contraception while taking ALPRIM. Taking ALPRIM with food will help reduce the chance of a stomach upset. ALPRIM is not recommended for use in children under 6 years of age, as the safety and effectiveness of ALPRIM in this age group has not been established. Occasionally, Alprim is used to treat other types of infections, such as chest infections and acne. Elsevier; 2020. https://www.clinicalkey.com. Improving clinical practice and health outcomes for Australia. U.S. District Judge Denise Cote, in New York, refused on Thursday to dismiss 72 lawsuits alleging taking Tylenol while pregnant increases the risks of children developing autism or ADHD. ALPRIM can be taken with or without food. or breathing; wheezing or shortness of breath. Alprim should not be given to patients with a history of trimethoprim hypersensitivity. Alphapharm Pty Ltd trading as Viatris Level 1, 30 The Bond30-34 Hickson RoadMillers Point NSW 2000www.viatris.com.auPhone: 1800 274 276. following: Your doctor may want to take special care if you have any of these conditions. Do this even if there are no signs of discomfort or poisoning. Do not give Alprim to children under the age of 6 years. The toxic drug levels of Alprim can result in the exacerbation of depression and anxiety. Heat and dampness can destroy some medicines. Visual appearance Following oral administration, 50% to 60% of trimethoprim is excreted in the urine within 24 hours, approximately 80% of which is unchanged parent drug. Keep your tablets in a cool dry place where the temperature stays below 30C and protect from light. Ask your doctor or pharmacist to answer any questions you may have. They may differ from the information contained in this leaflet. or yellowing of the eyes or skin. It works by stopping the growth of the bacteria that is causing your infection. Swallow the tablets whole with a glass of water. Some people may need to take folate supplements while taking ALPRIM. ALPRIM is not recommended during breastfeeding. Alprim is available only with a doctors prescription. If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist. Some medicines may be affected by ALPRIM, or may affect how well it works. Do not take ALPRIM after the expiry date (EXP) printed on the pack. ACE inhibitors, medicines used to treat high blood pressure and some heart conditions. Alprim can be taken with or without food. Some people may need to take folate supplements while taking Alprim. Alprim isn't the safest antibiotic to take in pregnancy. The dosage is based on your medical condition and response to treatment. Tell your doctor if you have, or have had, any medical conditions, especially the following: Your doctor may want to take special care if you have any of these conditions. Tell your doctor or pharmacist as soon as possible if you do not feel well while you A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. Mayo Clinic; 2019. Call the doctor if the fever is accompanied by a severe headache, stiff neck, shortness of breath, or other unusual signs or symptoms. These people may include the elderly, people with folate deficiency and people taking certain medicines. Ask your doctor about the risks and benefits of taking ALPRIM during pregnancy. Pathophysiology and treatment of fever in adults. Click here for an email preview. Renal failure is not a recognised side effect of Alprim, although manufacturers advise caution when treating elderly people and people with impaired renal function. Do not drive or operate machinery until you know how ALPRIM affects you. from light. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Drink cranberry juice. Alprim passes into breast milk and may affect your baby. 20 years of helping Australians make better decisions about medicines, medical tests and other health technologies. The person may feel pain on the tongue or in the mouth. Phone: 1800 274 276, Knowing how to respond when someone says theyre struggling with their mental health or even suicidal can be daunting. ALPRIM is used to treat infections of the urinary tract caused by bacteria. Enter other medications to view a detailed report. You may need to have regular blood tests. Enhance elimination through urine acidification. Each Alprim tablet contains trimethoprim 300 mg as the active ingredient. Do not be alarmed by this list of possible side effects. take a different dose. If you take too much ALPRIM, you may experience the following: nausea, vomiting, dizziness, headaches, confusion or mental depression. Use ALPRIM only as directed and consult a health care professional if pain or symptoms persist. Pregnancy Category C. Alprim has been shown to be teratogenic in the rat when given in doses 40 times the human dose. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. Geriatric Use: Clinical studies of Alprim tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Make sure you take sufficient warm clothing and all precautionary measures. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. See your doctor immediately if you notice any of the following: The above list includes serious side effects which may require medical attention. Immediately stop taking Alprim if skin rash or any other allergic reaction occurs. Usually avoid combinations; use it only under special circumstances. Do not take ALPRIM if the packaging is torn or shows signs of tampering or the tablets Overdose can occur slowly over a long period of time if your daily doses are too high. If your doctor tells you to stop taking ALPRIM, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over. If you take too much ALPRIM, you may experience the following: nausea, vomiting, dizziness, For adults and children over 12 years, the usual dose is one tablet daily. By Kelly Bilodeau, Former Executive Editor, Harvard Women's Health Watch. Keep your tablets in a cool dry place where the temperature stays below 30C and protect from light. Add If any of these effects last or get worse, tell your doctor or pharmacist promptly. ALPRIM is available only with a doctor's prescription. Different people may respond differently to ALPRIM, so your doctor may tell you to take a different dose. Immediately stop taking ALPRIM if skin rash or any other allergic reaction occurs. For most infections, ALPRIM is usually taken for 7 days. Give your child acetaminophen (Tylenol, others). Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Fever treatment: Quick guide to treating a fever, COVID-19 vaccines for kids: What you need to know, COVID-19 vs. flu: Similarities and differences. You may not experience any of them. Heat and dampness can destroy some medicines. your tablets as you would normally. ALPRIM can be taken with or without food. Keep ALPRIM where children cannot reach it. Your doctor has weighed the risks of you taking Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient. This information is not intended as a substitute for medical advice and should not be exclusively relied on to manage or diagnose a medical condition. All medicines can have side effects. Immediately stop taking ALPRIM if skin rash or any other allergic reaction occurs. Your infection may not clear completely if you stop taking your medicine too soon. Follow all directions given to you by your doctor and pharmacist carefully. Never take a double dose of Alprim, even if you have forgotten a dose. Alprim dosage The usual oral adult dosage is 100 mg of trimethoprim every 12 hours or 200 mg trimethoprim every 24 hours, each for 10 days. Do not stop taking ALPRIM, even if you feel better after a few days, unless advised by your doctor. in this leaflet. If you are not sure what to do or have any questions, ask your doctor or pharmacist. Store between 15-25C. can check on your progress. Do not store ALPRIM or any other medicine in the bathroom or near a sink. Enter other medications to view a detailed report. It does not take the place of talking to your doctor or pharmacist. https://www.uptodate.com/contents/search. ALPRIM is not recommended for use in children under 6 years of age, as the safety and effectiveness of ALPRIM in this age group has not been established. 6-24 months. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Of the total drug interactions, 7 are major, 68 are moderate, and 35 are minor. ALPRIM is available only with a doctor's prescription. Minimally clinically significant. ALPRIM is a 9.5 mm white normal convex tablet marked TM/300 on one side, G on the other. Nursing Mothers: Alprim is excreted in human milk. If your symptoms do not improve within a few days, or if they become worse, tell your Millers Point, NSW: Alphapharm Pty Ltd. October 2016. COVID-19: Who's at higher risk of serious symptoms? If you have not told your doctor about any of the above, tell him/her before you start Heres how to help, As Australias primary healthcare providers, all GPs can look after all Australians, but choice is available if you prefer a more focused approach. Millers Point, NSW: Alphapharm Pty Ltd. August 2013. active heart, zidovudine, zalcitabine or lamivudine; medicines used for certain viral infections, dapsone, a medicine used for leprosy or dermatitis herpetiformis, ciclosporin, a medicine used to help prevent organ transplant rejection or to treat Treatment of acute urinary tract infections caused by sensitive organisms. Tell all the doctors, dentists and pharmacists who are treating you that you are taking 3 disease interactions, and 1 alcohol/food interaction. www.viatris.com.au Read the label carefully for proper dosage, and be careful not to take more than one medication containing acetaminophen, such as some cough and cold medicines. Your doctor and pharmacist have more information on medicines Mayo Clinic; 2019. If your doctor or health visitor says your baby is healthy, you can take Alprim while breastfeeding.Alprim passes into breast milk in small amounts and is unlikely to cause side effects in your baby. Practical information, tools and resources for health professionals and staff to help improve the quality of health care and safety for patients. Making safe and wise decisions for biological disease-modifying antirheumatic drugs (bDMARDs) and other specialised medicines. These people may include the elderly, people with folate deficiency and people taking certain medicines. 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Enter other medications to view a detailed report. Ask your doctor if you have any questions about why ALPRIM has been prescribed for Check with your doctor as soon as possible if you have any problems while taking ALPRIM hepatic dysfunction. If you are not sure what to do or have any questions, ask your doctor or pharmacist. ALPRIM. The most important warning sign that Alprim is causing a serious side effect is usually a change in skin color. Some mixtures of medications can lead to serious and even fatal consequences. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Do not take ALPRIM if you are allergic to any other medicines containing trimethoprim or any of the ingredients listed at the end of this leaflet. Do this even if there are no signs of discomfort or poisoning. Talk to your doctor about the need for additional contraception while taking Alprim. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Alprim. Taking a double dose greatly increases the risk of side effects. These people may include the elderly, people with folate deficiency and people taking certain medicines. Heat and dampness can destroy some medicines. Please let your surgeon and anesthesia team know if you are taking these before surgery. Follow all directions given to you by your doctor and pharmacist carefully. the other. dose when you are meant to. May employ gastric lavage and forced diuresis. Do not drive or operate machinery until you know how Alprim affects you. These include: Your doctor can tell you what to do if you are taking any of these medicines. Some of the symptoms of an allergic reaction may include red, itchy skin rashes, itching Ward MA. Incompatibilities were either not assessed or not identified as part of the registration of this medicine. The above list includes serious side effects which may require medical attention. Your doctor may have prescribed ALPRIM for another reason. Parenting information is available at Parenthub.com.au, The Medical System Bulk Billing & Medicare, 10 tips for encouraging sharing (and discouraging self-interest) this Christmas. ALPRIM will not work against infections caused by viruses, such as colds or flu. There is no information concerning the right dose for children under the age of 6 ALPRIM will not work against infections caused by viruses, such as colds or flu. Swallow the tablets whole with a glass of water. This serious symptom may happen along with other side effects, MyDr.com.au reports 1 2. Timely, independent, evidence-based information on new drugs and medical tests, and changes to the PBS and MBS. Take Alprim by mouth with or without food as directed by your doctor, usually once or twice daily. The elderly and people with kidney problems may need smaller doses. Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. privacy practices. Doctors generally agree you should take it only if the benefits outweigh the risks. Do not take Alprim if you are allergic to any other medicines containing trimethoprim or any of the ingredients listed here. For children 6 to 12 years, the usual dose is half a tablet daily. Do not stop taking ALPRIM, even if you feel better after a few days, unless advised In terms of specifics: acetaminophen (Tylenol), naproxen (Aleve) or ibuprofen (Advil, Motrin) can help lower your fever, assuming you don't have a health history that should prevent you from using them. Swallow the tablets whole with a glass of water. There are 110 drugs known to interact with Tell your doctor if you are taking any other medicines, including any that you buy